Long-term effects of inflammation in people born with HIV
Long-term clinical and immunologic consequences of inflammation in perinatal HIV
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11381008
This project follows people born with HIV who have been on antiretroviral therapy to see how ongoing inflammation may affect their immune system, heart, metabolism, and thinking over many years.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11381008 on ClinicalTrials.gov |
What this research studies
You would join a long-term follow-up of people who acquired HIV at birth and have been on ART for about a decade, compared with people who were not exposed to HIV. Researchers will collect blood samples to measure immune and inflammatory markers and perform heart, metabolic, and neurocognitive tests. The study builds on a prior Kenyan cohort and will track changes over roughly 10 years to link immune activation with health outcomes. Visits will include clinical exams, laboratory testing, and standardized cognitive and cardiovascular measures.
Who could benefit from this research
Good fit: Ideal participants are people who acquired HIV at birth, have been on ART for many years (around a decade), and can attend repeated clinical and blood-sampling visits.
Not a fit: People without perinatal HIV or those who did not start or remain on long-term ART are unlikely to directly benefit from joining this study.
Why it matters
Potential benefit: If successful, this work could point to ways to reduce long-term inflammation and lower the risk of heart, metabolic, and cognitive problems for people born with HIV.
How similar studies have performed: Adult studies have linked chronic inflammation to age-related illnesses and a prior cross-sectional Kenyan study found persistent inflammation in children with perinatal HIV, but long-term follow-up like this is relatively new.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KHAITAN, ALKA — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: KHAITAN, ALKA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus