Long-term effects of Dengvaxia vaccine in the Philippines
Long-term safety and effectiveness of Dengvaxia in the Philippines
Researchers are tracking how safe Dengvaxia is and how well it protects people vaccinated in the Philippines, especially children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Hawaii at Manoa NIH-funded |
| Lab location | 1 site (Honolulu, United States) |
| Project ID | NIH-11146628 on NIH RePORTER |
What this research studies
This project follows people in the Philippines who received one or more doses of Dengvaxia during the 2016 school vaccination program and after later dengue infections. Researchers will collect blood samples to measure antibody levels, NS1 IgG, and T-cell responses and will link those lab results to clinical records of dengue illness and severity. The team will compare people who were dengue-seropositive before vaccination with those who were seronegative and will examine outcomes after 1, 2, or 3 doses. Your samples and health information could help explain who is at higher risk of severe dengue after vaccination and guide safer vaccine use.
Who could benefit from this research
Good fit: People who received Dengvaxia in the Philippines—particularly children and adolescents who got one or more doses and anyone who later had a dengue infection—are the ideal candidates.
Not a fit: Individuals who were never vaccinated with Dengvaxia or whose health issues are unrelated to dengue are unlikely to get direct benefit from this work.
Why it matters
Potential benefit: If successful, this work could help identify who is protected or at higher risk after Dengvaxia and inform safer vaccination policies and follow-up care.
How similar studies have performed: Prior trials showed Dengvaxia protects people who were dengue-seropositive and can increase risk in dengue-naive recipients, and this project builds on those findings by applying newer lab tests to real-world, partially dosed populations.
Where this research is happening
Honolulu, United States
- University of Hawaii at Manoa — Honolulu, United States (Active)
Researchers
- Principal investigator: Wang, Wei-Kung — University of Hawaii at Manoa
- Study coordinator: Wang, Wei-Kung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.