Long-term cognitive effects in breast cancer survivors after chemotherapy
Very-long Term Neurocognitive Outcomes in Breast Cancer Survivors (ProbC2)
This study is looking at how chemotherapy might affect thinking and memory over time in breast cancer survivors, comparing their experiences with those who haven't had chemotherapy and healthy individuals, to help understand how it impacts their daily lives.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-10771929 on NIH RePORTER |
What this research studies
This research investigates the long-term neurocognitive outcomes in breast cancer survivors who have undergone chemotherapy. It aims to understand how chemotherapy may accelerate cognitive decline and brain aging by comparing the cognitive functions of breast cancer survivors, chemotherapy-naïve patients, and healthy controls over a period of up to 10 years. Participants will undergo non-invasive neuroimaging and cognitive assessments at yearly intervals to track changes in brain structure and function. The study seeks to provide insights into the unique cognitive trajectories of these patients and the implications for their quality of life.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who have been treated for breast cancer with chemotherapy and are willing to participate in long-term cognitive assessments.
Not a fit: Patients who have not undergone chemotherapy or those with pre-existing cognitive impairments unrelated to cancer treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cognitive impairments in breast cancer survivors, enhancing their quality of life.
How similar studies have performed: Other research has shown significant cognitive impairments related to chemotherapy, but this study aims to extend the follow-up period significantly, making it a novel approach.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Palesh, Oxana G — Virginia Commonwealth University
- Study coordinator: Palesh, Oxana G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.