Long-term brain effects after adolescent organophosphate poisoning
Long-Term Consequences of Acute Organophosphate Intoxication in an Adolescent Rodent Model
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-11305151
This project looks at how organophosphate (nerve agent/pesticide) poisoning during adolescence can lead to seizures and lasting problems with memory and thinking.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-11305151 on ClinicalTrials.gov |
What this research studies
This work uses adolescent rats given exposures and the same emergency drugs people receive (atropine, pralidoxime, and midazolam) to mimic real-life poisoning and treatment. Animals are followed for eight weeks with continuous seizure monitoring, brain activity recordings, and tests of learning and memory. The team will track recovery of the enzyme acetylcholinesterase and whether that recovery relates to later seizures, drug effectiveness, or cognitive decline. Findings aim to reflect what teen survivors might experience so new approaches can be developed to protect the adolescent brain.
Who could benefit from this research
Good fit: This project does not enroll people; it uses adolescent rats to model organophosphate poisoning, so no patients can join this grant's experiments.
Not a fit: Because this is preclinical animal research, people who have been exposed to organophosphates will not directly receive treatment or clinical benefit from participation in this grant.
Why it matters
Potential benefit: If successful, the results could explain why standard emergency treatments sometimes fail and point to better ways to prevent seizures and long-term thinking problems after adolescent organophosphate poisoning.
How similar studies have performed: Related adult animal studies have linked prolonged acetylcholinesterase inhibition with higher seizure burden, but longitudinal work focused on adolescence and standard emergency treatments is new.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEIN, PAMELA J — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: LEIN, PAMELA J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.