Long-lasting dental restorations with hydrolysis-resistant resin networks
Official title: Hydrolysis-resistant resin networks for durable and multifunctional dental restorations
Funded at Ada Forsyth Institute, INC. · NIH-11365127 · Data updated 2026-11-12
A new kind of dental resin could make fillings last longer and resist decay by using durable, anti-bacteria materials.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ada Forsyth Institute, INC. NIH-funded |
| Lab location | 1 site (Somerville, UNITED STATES) |
| Project start | September 19, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $449,844 |
| NIH project number | 5R01DE033442-03 |
| Project ID | NIH-11365127 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include adults receiving dental composite restorations who are at risk for secondary caries or restoration failure.
✕Less likely to help
Patients with non-restorative dental needs or those not requiring adhesives or methacrylate-based resins may not directly benefit.
What this research studies
This project aims to create and test advanced resin networks and additives that resist breakdown in the mouth and fight common causes of restoration failure. Researchers will design biostable resins with hydrophobic components and self-etch adhesive features, then evaluate their performance in lab tests that mimic oral conditions. The work seeks to extend the lifespan of composite restorations beyond what current methacrylate-based materials can offer. If successful, these materials could reduce secondary caries and improve long-term dental health for patients.
Why it matters
Potential benefit: If successful, patients could receive dental restorations that last longer and resist decay and bacterial attack, reducing the need for frequent replacements.
How similar studies have gone: Previous methacrylate-based resins have shown limitations; this project explores a novel hydrolysis-resistant approach with antimicrobial and protein-repellent features, which is promising but still exploratory.
Where this research is happening
-
Ada Forsyth Institute, INC.
Somerville, United States Active
Researchers
- Principal investigator: Sun, Jirun — Ada Forsyth Institute, INC.
- Study coordinator: Sun, Jirun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.