LncRNA targets for heart disease in adults
Official title: LncRNA-PTPRE in cardiac dysfunction
Funded at New York Inst of Technology · NIH-11361220 · Data updated 2026-11-12
A patient-focused project explores how heart-related long noncoding RNAs influence heart failure in adults with atherosclerotic disease.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Inst of Technology NIH-funded |
| Lab location | 1 site (Old Westbury, United States) |
| Project start | July 15, 2026 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $573,750 |
| NIH project number | 1R15HL173850-01A1 |
| Project ID | NIH-11361220 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with atherosclerotic cardiovascular disease and heart dysfunction who may benefit from future targeted therapies.
✕Less likely to help
Results may not benefit patients if findings do not translate into effective treatments or if the studied pathways are not modifiable.
What this research studies
This NIH grant looks at how noncoding RNA molecules in the heart may affect heart function and potentially offer new ways to treat heart failure in people with ASCVD. Researchers will study the connections between long noncoding RNAs and thyroid hormone pathways in heart tissue, aiming to identify heart-specific targets. The work involves analyses that could inform future diagnostics or therapies that directly impact patients with ischemic heart disease. If successful, findings might lead to new strategies to protect heart function and reduce heart failure risk.
Why it matters
Potential benefit: Potentially new diagnostic markers or therapeutic targets to improve heart function in ASCVD patients.
How similar studies have gone: Previous work suggests lncRNAs play a role in heart biology, but detailed mechanisms in human heart tissue remain underexplored.
Where this research is happening
-
New York Inst of Technology
Old Westbury, United States Active
Researchers
- Principal investigator: Rajagopalan, Viswanathan — New York Inst of Technology
- Study coordinator: Rajagopalan, Viswanathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.