Liver Cell Structures and Cancer Risk
Nuclear envelope and predisposition to hepatic neoplasia
This project explores how changes in the protective layer of liver cells might increase the risk of developing liver cancer, especially for those with chronic liver conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hackensack University Medical Center NIH-funded |
| Lab location | 1 site (Hackensack, United States) |
| Project ID | NIH-11144524 on NIH RePORTER |
What this research studies
Many people with long-term liver conditions, like nonalcoholic steatohepatitis, face a higher chance of developing liver cancer, but we don't fully understand the reasons behind this. This project focuses on the 'nuclear envelope,' a protective layer inside liver cells, and a specific protein called LAP1. Researchers believe that changes in LAP1, such as a switch in its form, could make liver cells more vulnerable to developing cancer. By uncovering these fundamental mechanisms, we aim to better understand why liver cancer develops and potentially discover new ways to prevent or treat it.
Who could benefit from this research
Good fit: This foundational research does not currently involve direct patient participation.
Not a fit: Patients not at risk for or diagnosed with hepatocellular carcinoma would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify individuals at high risk for liver cancer or develop new strategies for prevention and treatment.
How similar studies have performed: This project builds on the researchers' own preliminary findings regarding the LAP1 protein's role in liver cell changes, suggesting a novel approach to understanding liver cancer development.
Where this research is happening
Hackensack, United States
- Hackensack University Medical Center — Hackensack, United States (Active)
Researchers
- Principal investigator: Shin, Ji-Yeon — Hackensack University Medical Center
- Study coordinator: Shin, Ji-Yeon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.