Lipid movement sensors in the kidney and high blood pressure
Official title: Lipid Rafts: Mechanosensors of the distal nephron
Funded at Northport VA Medical Center · NIH-11424319 · Data updated 2026-11-12
This NIH grant explores how cholesterol transport in the kidney affects salt handling and high blood pressure in adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northport VA Medical Center NIH-funded |
| Lab location | 1 site (Northport, United States) |
| Project start | October 1, 2016 |
| Project end | December 31, 2027 |
| Funding year | 2026 |
| NIH project number | 5I01BX003015-09 |
| Project ID | NIH-11424319 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with or at risk for hypertension who could provide biological samples or participate in future translational studies.
✕Less likely to help
People without hypertension or related kidney issues may not directly benefit from this research.
What this research studies
Adult patients with hypertension or at risk for it could be affected by this work. The project looks at how cholesterol leaving cells in the kidney interacts with salt processing to influence blood pressure, focusing on ABCA1 and related transporters. Researchers may use human tissue samples or models to study how changes in cholesterol transport alter kidney function and sodium balance. The findings could point to new ways to prevent or manage high blood pressure by targeting kidney cholesterol pathways.
Why it matters
Potential benefit: If successful, this research could lead to new strategies to prevent or manage hypertension by modulating kidney cholesterol transport.
How similar studies have gone: Previous animal and human studies suggest a link between cholesterol transport and blood pressure, but direct human data are still limited.
Where this research is happening
-
Northport VA Medical Center
Northport, United States Active
Researchers
- Principal investigator: Rohatgi, Rajeev — Northport VA Medical Center
- Study coordinator: Rohatgi, Rajeev
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.