Linking tumor genetic tests and medical records to improve cancer care
Project 1: Overcoming methodologic barriers to analysis of observational clinico-genomic data in oncology
This project develops tools that pull treatment responses from medical records and match them with tumor genetic tests to help people with cancer get more personalized care.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11181546 on NIH RePORTER |
What this research studies
Researchers will build and test methods to extract key cancer outcomes—like treatment response and follow-up—from unstructured electronic health records. They will combine artificial intelligence, standardized medical-chart annotation, and targeted manual review to convert notes and reports into consistent, usable data. The team will link those clinical outcomes to tumor genomic results across large databases and adjust for real-world testing and follow-up patterns. The methods will be refined and validated so the resulting clinico-genomic datasets are reproducible and useful across hospitals.
Who could benefit from this research
Good fit: People with cancer who have had tumor genomic testing and whose treatment and outcomes are recorded in electronic health records at participating cancer centers would be most relevant to this work.
Not a fit: Patients without tumor genomic testing, with incomplete or inaccessible medical records, or who receive care outside participating systems are less likely to benefit directly.
Why it matters
Potential benefit: If successful, these tools could speed discovery of genetic markers that help match patients to more effective therapies and make real-world data more useful for personalized care.
How similar studies have performed: Previous work using AI and manual chart review has shown promise for extracting outcomes from EHRs, but scalable, standardized clinico-genomic linkage across centers remains relatively novel.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Schrag, Deborah — Sloan-Kettering Inst Can Research
- Study coordinator: Schrag, Deborah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.