Linking genetic risk factors for age-related macular degeneration to lipid levels and cell function in retinal cells.
Correlating Genomic AMD Risk Variants with Lipid Composition and Phagocytic Function of Patient-Derived Induced Pluripotent Stem Cell (iPSC)-derived Retinal Pigment Epithelium (RPE)
['FUNDING_U01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11257982
This study is looking at how certain genes linked to age-related macular degeneration (AMD) affect the health and function of eye cells from patients, with the goal of finding out more about the disease and discovering new ways to treat it.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11257982 on ClinicalTrials.gov |
What this research studies
This research investigates how specific genetic variants associated with age-related macular degeneration (AMD) influence the lipid composition and phagocytic function of retinal pigment epithelium (RPE) cells derived from patients' induced pluripotent stem cells (iPSCs). By analyzing these patient-derived cells, the study aims to understand the cellular mechanisms that contribute to AMD. The approach involves correlating genomic data with cellular behavior and lipid profiles, which may provide insights into disease progression and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic predispositions to age-related macular degeneration.
Not a fit: Patients without genetic risk factors for age-related macular degeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with age-related macular degeneration.
How similar studies have performed: Previous research has shown promising results in correlating genetic factors with cellular functions in other conditions, suggesting potential for success in this novel approach.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SKOWRONSKA-KRAWCZYK, DOROTA — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: SKOWRONSKA-KRAWCZYK, DOROTA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.