Linking genetic changes in single cells to their characteristics in cancer
Expanding the GoT toolkit to link single-cell clonal genotypes with protein, transcriptomic, epigenomic and spatial phenotypes
This study is looking at how certain genetic changes in individual cancer cells can affect how the cancer grows and responds to treatment, helping us understand why some patients might struggle with their therapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10886692 on NIH RePORTER |
What this research studies
This research investigates how specific genetic mutations in single cells contribute to the development of cancer and treatment resistance. By utilizing advanced multi-omic technologies, the study captures various biological information from individual cells, including their genetic makeup, gene expression, and protein levels. This approach allows researchers to compare mutated cells, which may thrive in cancer, against normal cells within the same patient, providing insights into cancer evolution and treatment challenges.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with B-cell chronic lymphocytic leukemia or other related cancers who are undergoing treatment.
Not a fit: Patients with early-stage cancers or those not diagnosed with B-cell chronic lymphocytic leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment strategies for cancers, particularly those that develop resistance to current therapies.
How similar studies have performed: Previous research utilizing multi-omic approaches has shown promise in understanding cancer biology, suggesting that this study builds on established methodologies.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Landau, Dan — Weill Medical Coll of Cornell Univ
- Study coordinator: Landau, Dan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.