Linking blood and tissue tests to bone marrow transplant and CAR T therapy outcomes
Correlative Science
This project builds a large bank of patient blood and tissue samples and new lab tests to help understand what happens after bone marrow transplant and CAR T cell therapy.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11197511 on NIH RePORTER |
What this research studies
We collect and store plasma, peripheral blood mononuclear cells (PBMCs), and other tissue samples from people undergoing hematopoietic cell transplantation, related donors, and CAR T cell therapy, along with their clinical data. The core runs specialized correlative laboratory assays and single-cell RNA sequencing and maintains data and metadata analysis pipelines to connect lab findings with patient outcomes. Over 100,000 plasma and 85,000 PBMC samples are already archived and made available under IRB-approved protocols for translational research. By keeping longitudinal samples, researchers can track immune and molecular changes before and after treatment to inform future care.
Who could benefit from this research
Good fit: Ideal participants are people receiving hematopoietic cell (bone marrow) transplantation or CAR T cell therapy, as well as related/unrelated donors who can provide blood or tissue samples under a Stanford IRB protocol.
Not a fit: Patients with conditions unrelated to bone marrow transplant or cellular therapies are unlikely to be directly affected or enrolled in this biobank-focused work.
Why it matters
Potential benefit: If successful, this work could help predict who will benefit or face complications from transplants or CAR T therapy and support more personalized, safer treatment plans.
How similar studies have performed: Similar biobanking efforts and correlative single-cell assays in transplantation and cell therapy have produced useful insights, though many findings remain exploratory and require further validation.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Miklos, David B. — Stanford University
- Study coordinator: Miklos, David B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.