Linking aging biomarkers to cognitive and physical decline in older adults
Statistical Models and Mechanisms Linking Biomarkers of Aging to Cognitive-Physical Decline and Dementia
This study is looking at how signs of aging might be linked to memory problems and physical challenges in older adults, especially those with Alzheimer’s and similar conditions, to find ways to help prevent dementia and improve overall health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10513438 on NIH RePORTER |
What this research studies
This research investigates how biological markers of aging are connected to cognitive decline and physical disabilities in older adults, particularly focusing on Alzheimer’s disease and related dementias. By examining factors such as inflammation and cellular changes, the study aims to identify potential intervention targets that could prevent dementia and improve physical health. The approach combines insights from geroscience, which suggests that addressing the biology of aging may be more effective than targeting specific diseases. Participants may undergo assessments related to their cognitive and physical performance to help establish these connections.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those at risk for cognitive decline or dementia.
Not a fit: Patients who are younger than 21 or those without any cognitive or physical decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing dementia and physical disabilities in older adults.
How similar studies have performed: Previous research has shown promising results in linking biomarkers of aging to cognitive and physical health, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Shardell, Michelle Denise — University of Maryland Baltimore
- Study coordinator: Shardell, Michelle Denise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.