Link between early Candida infections and severe tooth decay in young children
Association between early Candida infection (oral thrush) and severe early childhood caries
This study is looking at how early oral thrush in young kids might be linked to serious tooth decay, and it aims to help us find ways to prevent and treat these dental issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11129405 on NIH RePORTER |
What this research studies
This research investigates the connection between early Candida infections, commonly known as oral thrush, and the development of severe early childhood caries (S-ECC) in children under 11 years old. The study aims to enhance understanding of how Candida albicans may contribute to tooth decay by examining the oral microbiome and its impact on dental health. By utilizing advanced clinical study designs and interdisciplinary expertise, the research will follow children over time to gather comprehensive data on their oral health and infections. This approach aims to identify potential preventive measures and treatments for S-ECC.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under the age of 11 who have experienced early Candida infections or are at risk for severe early childhood caries.
Not a fit: Patients who are older than 11 years or do not have a history of Candida infections or severe tooth decay may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for severe tooth decay in young children.
How similar studies have performed: Previous research has indicated a potential link between oral fungal infections and dental health, suggesting that this investigation could build on existing knowledge in this area.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Liu, Yuan — Temple Univ of the Commonwealth
- Study coordinator: Liu, Yuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.