Light-powered creation of axis-locked N-heterocycles for medicines
Official title: Light-Induced Atroposelective N-Heterocyclization via Chiral Perovskite Nanocrystals
Funded at San Diego State University · NIH-11325857 · Data updated 2026-11-12
A new light-activated method uses chiral perovskite catalysts to directly make axial chiral N-heterocycles that are important in pharmaceutical compounds.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Diego State University NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | August 1, 2022 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $376,250 |
| NIH project number | 5R35GM147260-05 |
| Project ID | NIH-11325857 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients directly; research focuses on chemical methodologies for pharmaceutical synthesis.
✕Less likely to help
No direct patient participation in this grant.
What this research studies
This research will explore a visible-light driven catalytic approach to form axially chiral N-heterocycles, using chiral semiconductor perovskites derived from common solar cell materials. The work aims to enable direct, asymmetric ring-closure steps that were previously difficult, potentially simplifying how certain drug-building blocks are produced. The project combines chemistry, materials science, and practical laboratory methods to create scalable, bench-top processes for pharmaceutical synthesis. If successful, the method could provide a new toolkit for manufacturing complex bio-relevant molecules with high stereo control.
Why it matters
Potential benefit: If successful, this approach could streamline the production of important drug-like molecules, potentially reducing cost and time.
How similar studies have gone: This is an innovative method with potential high impact, building on established light-driven asymmetric chemistry but introducing a novel chiral perovskite catalyst.
Where this research is happening
-
San Diego State University
San Diego, United States Active
Researchers
- Principal investigator: Yan, Yong — San Diego State University
- Study coordinator: Yan, Yong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.