Lewis base ligands to control carbon–carbon bond formation
Official title: Lewis Base Ligands Designed to Control Carbon-Carbon Bond Formation
Funded at Texas A&m University · NIH-11359738 · Data updated 2026-11-12
This NIH grant supports research to develop new chemical methods that could help make medicines more efficiently by controlling how carbon–carbon bonds are formed.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $368,460 |
| NIH project number | 5R35GM151018-04 |
| Project ID | NIH-11359738 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients directly; could lead to better drug manufacturing processes benefiting patients.
✕Less likely to help
No direct patient involvement; this is foundational chemistry research.
What this research studies
Researchers at Texas A&M University are exploring how special Lewis base ligands can steer reactions to form carbon–carbon bonds with high precision. The work focuses on asymmetric synthesis and advances in bond-forming processes to improve steps toward making therapeutic molecules. The study combines fundamental chemistry with practical aims to enable better, faster drug synthesis that could benefit patients in the future. Progress could lead to cleaner, more sustainable routes to medicines and materials.
Why it matters
Potential benefit: Potentially faster and cleaner ways to make important medicines.
How similar studies have gone: Other groups have shown that advanced ligand design can enable selectivity in complex bond formations, with positive implications for drug synthesis.
Where this research is happening
-
Texas A&m University
College Station, United States Active
Researchers
- Principal investigator: Thomas, Andy Alexander — Texas A&m University
- Study coordinator: Thomas, Andy Alexander
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.