Letrozole for Uterine Fibroids
Letrozole for Treatment of Uterine Fibroids: A randomized, placebo-controlled trial
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11141798
This project is exploring if a medication called letrozole can help women with uterine fibroids reduce their symptoms and potentially avoid surgery.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11141798 on ClinicalTrials.gov |
What this research studies
Uterine fibroids are common growths that can cause heavy bleeding, pain, and other issues for many women. While surgery is a common treatment, it requires a long recovery, and many women prefer other options. This project is looking into letrozole, a medication that works by reducing estrogen, which fibroids need to grow. The goal is to see if letrozole can shrink fibroids and relieve symptoms without the need for surgery or the side effects of other hormone therapies.
Who could benefit from this research
Good fit: Ideal candidates for this work would be premenopausal women experiencing symptoms from uterine fibroids who are seeking alternatives to surgery.
Not a fit: Patients who have already undergone surgery for fibroids or those with contraindications to hormone-affecting medications may not receive benefit.
Why it matters
Potential benefit: If successful, this could offer women a new, non-surgical treatment option for uterine fibroids that avoids the side effects of current hormone therapies.
How similar studies have performed: While letrozole is used for other conditions, its effectiveness specifically for uterine fibroids in a randomized, placebo-controlled setting is being rigorously tested in this trial.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JACOBY, VANESSA — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: JACOBY, VANESSA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.