Leptin's Role in Healthy Aging and Longevity
Effects of leptin modulation on health span and lifespan
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · NIH-11195639
This research explores how adjusting a hormone called leptin might help us live longer, healthier lives, especially as we age.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCIENCE CENTER (nih funded) |
| Locations | 1 site (SAN ANTONIO, UNITED STATES) |
| Trial ID | NIH-11195639 on ClinicalTrials.gov |
What this research studies
Aging often leads to more belly fat, which can increase a hormone called leptin and make our bodies less responsive to it. Our previous work suggests that too much leptin can contribute to obesity and related health issues, even those caused by certain medications. This project aims to understand if reducing leptin can protect against obesity and improve how our body's cells function. We are using special mouse models and tools to see if controlling leptin levels can extend both healthy years and overall lifespan.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but focuses on understanding biological mechanisms relevant to individuals experiencing age-related weight gain or metabolic issues.
Not a fit: Patients looking for immediate new treatments or direct clinical intervention would not find this particular grant directly beneficial for participation.
Why it matters
Potential benefit: If successful, this work could lead to new ways to manage age-related obesity and improve overall health and longevity.
How similar studies have performed: Previous publications and preliminary results from this team suggest that reducing leptin can protect against obesity and extend lifespan in animal models.
Where this research is happening
SAN ANTONIO, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCIENCE CENTER — SAN ANTONIO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHAO, SHANGANG — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
- Study coordinator: ZHAO, SHANGANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.