Learning how heart and muscle proteins work to improve treatments
Understanding membrane proteins’ allosteric modulation with cryo-EM
This research helps us understand how important proteins in your heart and muscles work, aiming to develop new medicines for heart and muscle conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11091500 on NIH RePORTER |
What this research studies
Our bodies rely on tiny proteins on cell surfaces to send signals, especially in the heart and muscles. This project uses advanced imaging, called cryo-electron microscopy, to create detailed pictures of these proteins. By understanding how different molecules interact with these proteins, we can learn how they control important functions like calcium signaling. This knowledge is key to developing new and better treatments for heart and muscle diseases.
Who could benefit from this research
Good fit: This foundational research is relevant for anyone affected by or at risk for cardiac diseases or muscle disorders.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention will not receive direct benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new and more effective medications for various heart and muscle conditions.
How similar studies have performed: Cryo-electron microscopy and molecular dynamics are established techniques, and similar approaches have successfully revealed structures of other important proteins, but this specific application to cardiac and muscle receptors for therapeutic design is an active area of discovery.
Where this research is happening
New York, United States
- New York University — New York, United States (Active)
Researchers
- Principal investigator: Des Georges, Amedee — New York University
- Study coordinator: Des Georges, Amedee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.