Learn-As-you-GO: smarter, adjustable heart and blood-pressure care programs
Learn-As-you-GO (LAGO): An innovative adaptive design for multi-component intervention studies in cardiology and public health
This project uses a method to change and fine-tune multi-part programs (nurse support, home blood-pressure monitors, medication help, and EHR tools) over time to better help people with high blood pressure and heart disease risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11289374 on NIH RePORTER |
What this research studies
This grant develops an adaptive trial approach that changes the 'dose' and mix of intervention parts as the study progresses to find the most effective and cost-conscious combination for patients. The team will use examples like nurse-led care coordination, nurse-managed medication protocols with adherence counseling, home blood-pressure monitoring, and electronic health record tools to show how components can be adjusted at pre-set stages. The method aims to preserve statistical validity while reducing the chance a trial fails because its fixed plan was suboptimal. That adaptive method is meant to help future programs be both more effective and better tailored to real clinic settings.
Who could benefit from this research
Good fit: People with high blood pressure or at elevated cardiovascular risk who could receive nurse-led care, medication management, home blood-pressure monitoring, or EHR-linked support are the most relevant candidates.
Not a fit: People without hypertension or cardiovascular risk, or those unable or unwilling to use home BP monitors or participate in nurse-led programs, are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this could produce more effective, personalized intervention packages that improve blood pressure control and reduce heart disease risk.
How similar studies have performed: Previous multi-component programs (nurse care coordination, home BP monitoring, adherence counseling) have improved blood pressure in other trials, while using an adaptive Learn-As-you-GO design to fine-tune component doses is a new approach.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Spiegelman, Donna L — Yale University
- Study coordinator: Spiegelman, Donna L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.