Labeling cells involved in drug abuse behavior
Epigenomic labeling of cells that drive drug abuse behavior
This study is looking at how certain brain cells are involved in craving opioids, with the goal of finding better treatments to help people with opioid use disorder avoid relapse and feel better overall.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10874482 on NIH RePORTER |
What this research studies
This research investigates how specific cells in the brain contribute to opioid-seeking behavior by examining their unique epigenomic profiles. Using advanced techniques, the researchers aim to map the chromatin regions in the nucleus accumbens of mice, which are linked to addiction. By identifying and labeling these cells, the study seeks to develop targeted therapies that can help prevent relapse in individuals with opioid use disorder. This approach could lead to more effective treatments that minimize side effects and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with opioid use disorder or those at risk of developing addiction due to chronic pain management.
Not a fit: Patients who do not have a history of opioid use or are not affected by opioid use disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively reduce opioid addiction and improve recovery outcomes for patients.
How similar studies have performed: Other research has shown promise in targeting epigenomic changes in addiction, suggesting that this innovative approach could yield significant advancements in treatment.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Renthal, William Russell — Brigham and Women's Hospital
- Study coordinator: Renthal, William Russell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.