Lab models and resources for diffuse large B‑cell lymphoma
Core 1: Lymphoma models
['FUNDING_P01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11167665
This project builds mouse models, patient-derived tumor samples, and lab-grown tumor organoids to help researchers better understand and treat diffuse large B‑cell lymphoma (DLBCL).
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11167665 on ClinicalTrials.gov |
What this research studies
Researchers will assemble and share a large set of lymphoma research tools including engineered mouse models, patient-derived tumor xenografts (PDX), PDX-derived cell lines, and patient-derived organoids. They will profile these samples with antibody panels and molecular tests such as whole-exome sequencing and RNA sequencing to map genetic and gene-expression features. The team will use both lab (in vitro) and animal (in vivo) platforms, including humanized models, to study how defects in chromatin and 3D genome organization drive DLBCL. These resources will be provided to collaborating project teams to link specific genetic lesions to tumor behavior and treatment responses.
Who could benefit from this research
Good fit: People diagnosed with diffuse large B‑cell lymphoma (DLBCL) or patients willing to donate tumor tissue or clinical data for research would be the ideal candidates to help this effort.
Not a fit: People without DLBCL or individuals who cannot or choose not to provide tissue samples are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could speed discovery of targeted therapies and improve how doctors predict which treatments might work for people with DLBCL.
How similar studies have performed: Patient-derived xenografts and organoids have been useful in cancer research before, though applying them specifically to DLBCL chromatin and 3D genome questions is a more recent and specialized approach.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: INGHIRAMI, GIORGIO — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: INGHIRAMI, GIORGIO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.