Lab method to see if medicines help people resist drinking and avoid heavy drinking
Developing a novel human laboratory paradigm for AUD medication screening: Modeling the ability to resist drinking and heavy drinking
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-11168801
This project tries out lab tasks to see whether medicines can help adults with alcohol use disorder resist urges to drink and avoid heavy drinking.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11168801 on ClinicalTrials.gov |
What this research studies
You would come to a Yale lab to take part in controlled drinking sessions that mimic real-world urges and choices about alcohol. The team is adapting an 'ability to resist' task they developed for smoking to measure whether a pill helps you delay or skip drinking. They will create two versions of the task that match meaningful clinical outcomes like staying abstinent or having no heavy-drinking days. Over the two-year project they will refine these lab tests so they can be used to screen new medications more quickly.
Who could benefit from this research
Good fit: Adults with alcohol use disorder or those who regularly have heavy drinking episodes and who can attend in-person lab visits would be ideal candidates.
Not a fit: People without problematic drinking, pregnant people, or those with certain serious medical conditions or who cannot come to New Haven may not benefit from participating.
Why it matters
Potential benefit: If successful, this could speed up finding medicines that reduce drinking and help more people get effective treatments sooner.
How similar studies have performed: Related 'ability to resist' lab models for smoking have predicted medication effects, but applying this approach to alcohol is new.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCKEE, SHERRY ANN — YALE UNIVERSITY
- Study coordinator: MCKEE, SHERRY ANN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.