Korean Angelica extract to delay prostate cancer progression
Early clinial trials for Angelica herbal supplements for prostate cancer interception
Testing whether an oral extract from Korean Angelica can help men with rising PSA after prostate cancer treatment delay the need for hormone therapy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-11176167 on NIH RePORTER |
What this research studies
This project will give an oral extract made from Korean Angelica to men whose PSA levels are rising after surgery or radiation to see if it slows cancer progression. Dosage and scheduling are guided by animal studies and earlier human pharmacokinetic tests, and participants will have regular PSA and clinical monitoring. Researchers will also measure immune and inflammation markers to understand how the extract may work. The aim is to postpone or avoid starting androgen-deprivation therapy and its side effects.
Who could benefit from this research
Good fit: Ideal candidates are men with biochemical recurrence of prostate cancer (rising PSA after prostatectomy or radiation) who are not yet on hormone therapy.
Not a fit: Men already on androgen-deprivation therapy, with widespread metastatic disease, or with medical contraindications to herbal supplements are unlikely to benefit from this approach.
Why it matters
Potential benefit: If successful, the extract could delay or reduce the need for androgen-deprivation therapy, lowering treatment-related side effects.
How similar studies have performed: Preclinical animal studies and early human pharmacokinetic data are promising, but direct clinical evidence of benefit in prostate cancer is currently limited.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: Lu, Junxuan — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Lu, Junxuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.