Knight Alzheimer's Disease Cohort — St. Louis
Clinical Core
This program follows people with and without Alzheimer's in the St. Louis area over time to collect clinical information, brain scans, and biological samples.
Quick facts
| Grant type | P30 center grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11382430 on NIH RePORTER |
What this research studies
You would join a group of about 300 people who come to Washington University for an initial exam and yearly follow-ups with a study partner. Visits include memory and behavior interviews, neurologic exams, and standardized tests from the Uniform Data Set, plus brain imaging (MRI, amyloid PET, tau PET) and optional samples such as blood, CSF, skin cells, and iPSCs. The team works to make the group reflect the St. Louis population and keeps detailed records to track how cognition and biomarkers change over time. Participation supports comparison of symptomatic Alzheimer's, preclinical changes, and cognitively unimpaired aging.
Who could benefit from this research
Good fit: Ideal participants are older adults in the St. Louis area with or without memory problems who can attend annual visits, bring a study partner, and agree to imaging and sample collection.
Not a fit: People who live far from St. Louis, are unwilling to undergo imaging or provide biological samples, or expect immediate therapeutic benefit are unlikely to gain direct benefits from participation.
Why it matters
Potential benefit: If successful, this work could help detect Alzheimer's earlier and guide development of better diagnostics and treatments.
How similar studies have performed: Long-running cohorts like the Knight ADRC and other Alzheimer's centers have produced many important findings linking clinical change to imaging and biomarkers, so this is a proven approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Morris, John — Washington University
- Study coordinator: Morris, John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.