Klotho protein and protection of brain connections in early Alzheimer's
KLOTHO and Resilience to Synaptic Dysfunction in Preclinical AD
This project looks at whether higher Klotho protein levels help protect brain connections and memory in people with early Alzheimer's-related changes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11285359 on NIH RePORTER |
What this research studies
If you join, researchers will measure Klotho levels and markers of synaptic (brain connection) health alongside memory tests and Alzheimer’s biomarkers. They will use brain imaging and biological samples and follow people over time to see how synapses and thinking change. The team will compare people with different Klotho levels to see if higher Klotho links with resilience to synaptic loss and slower cognitive decline. Findings will combine human observations with laboratory studies to understand how Klotho might protect the brain.
Who could benefit from this research
Good fit: Adults with early Alzheimer’s-related brain changes or increased risk for AD (for example positive amyloid biomarkers or family history) are the most likely candidates for participation.
Not a fit: People with advanced dementia or brain problems unrelated to Alzheimer’s pathology are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could point to Klotho-related markers or treatments that help preserve synapses and slow memory decline in people at risk for Alzheimer’s.
How similar studies have performed: Prior animal and lab studies suggest Klotho can protect synapses and support cognition, but translating those findings to people is still early and not yet proven.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Frahmand, Ira — University of Wisconsin-Madison
- Study coordinator: Frahmand, Ira
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.