Kidney tubule damage and function in adult polycystic kidney disease
Kidney Tubular Damage and Dysfunction in Autosomal Dominant Polycystic Kidney Disease
This project checks blood and urine markers of kidney tubule injury in people with ADPKD to find early signs that predict faster loss of kidney function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11324018 on NIH RePORTER |
What this research studies
You would give blood and urine samples so researchers can measure a focused "kidney tubule health panel" that looks at injury, inflammation, repair, fibrosis, and secretion. The team will compare these marker levels in people with ADPKD to existing groups and relate them to kidney function and cyst growth over time. They will use both stored samples and new patient visits to see which markers best signal higher risk of progression. The goal is to identify people who might benefit from closer monitoring or who should be prioritized for future clinical trials and treatments.
Who could benefit from this research
Good fit: Adults diagnosed with autosomal dominant polycystic kidney disease who can provide blood and urine samples and share clinical information are ideal candidates.
Not a fit: People without ADPKD or those whose kidneys are already severely damaged with little remaining function may not see direct benefit from early-risk marker findings.
Why it matters
Potential benefit: If successful, this could help detect people with ADPKD who are at higher risk earlier and guide more personalized care or trial enrollment.
How similar studies have performed: Similar tubule-marker panels have shown usefulness in other kidney diseases such as chronic kidney disease and heart failure, but applying them specifically to ADPKD is relatively new.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Garimella, Pranav — University of California, San Diego
- Study coordinator: Garimella, Pranav
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.