Kidney Tissue Atlas for Acute and Chronic Kidney Disease
KPMP Kidney Mapping and Atlas Project (KMAP)
['FUNDING_U01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11400248
Creating a detailed, searchable map of kidney tissue using biopsy samples from people with acute kidney injury and chronic kidney disease to help find new treatment targets.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11400248 on ClinicalTrials.gov |
What this research studies
This project will create a Kidney Tissue Atlas using biopsy samples from people with acute kidney injury (AKI) and chronic kidney disease (CKD). The team will apply high-resolution imaging and spatial genomics to map which cell types, interstitial components, and molecular pathways are present or altered in different disease settings. The atlas will be interactive and searchable so researchers, clinicians, and patients can view raw data, spatial gene maps, and curated tissue maps. The goal is to define more precise disease subgroups and reveal potential targets for new therapies.
Who could benefit from this research
Good fit: Adults diagnosed with acute kidney injury or chronic kidney disease who can provide a kidney biopsy sample or allow their biopsy tissue and clinical data to be used for research.
Not a fit: People without AKI or CKD, those unable or unwilling to undergo biopsy, or those seeking immediate personal treatment changes may not receive direct benefit from participation.
Why it matters
Potential benefit: If successful, the atlas could help doctors and researchers identify the specific cells and pathways causing a person's kidney problem, enabling development of more targeted treatments.
How similar studies have performed: Earlier KPMP efforts and other tissue atlas projects have already revealed new cell types and molecular signatures, so this work builds on established successes.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KRETZLER, MATTHIAS — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: KRETZLER, MATTHIAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.