Kidney Tissue Atlas for Acute and Chronic Kidney Disease
KPMP Kidney Mapping and Atlas Project (KMAP)
['FUNDING_U01'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11174451
Building a detailed map of kidney tissue from people with acute and chronic kidney disease to help researchers find the cells and pathways behind illness.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11174451 on ClinicalTrials.gov |
What this research studies
This project will create an interactive Kidney Tissue Atlas by analyzing biopsy samples from people with acute kidney injury (AKI) and chronic kidney disease (CKD). The team will use multiple lab techniques, including spatial genomics and high-resolution imaging, to identify specific cell types and tissue patterns within the kidney. These multimodal data will be combined into a searchable online atlas using advanced visualization tools and standardized data models. The atlas and supporting data systems are designed so clinicians, researchers, and patients can explore findings and support future therapy development.
Who could benefit from this research
Good fit: People with AKI or CKD who are undergoing clinically indicated kidney biopsies at participating KPMP centers are the ideal candidates to contribute tissue samples.
Not a fit: People without kidney disease, those not undergoing a biopsy, or anyone expecting immediate personal treatment benefit from participation are unlikely to receive direct benefit.
Why it matters
Potential benefit: If successful, the atlas could help doctors classify types of kidney disease more precisely and point researchers toward new treatment targets.
How similar studies have performed: This builds on the first KPMP funding cycle that produced an initial kidney atlas and shared tools, so it extends previously successful work rather than being entirely novel.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KRETZLER, MATTHIAS — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: KRETZLER, MATTHIAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.