Keeping the BubR1 protein stable during aging and stress
Official title: Regulatory Mechanisms Governing BubR1 Protein Stability During Stress and Aging
Funded at Creighton University · NIH-11308261 · Data updated 2026-11-12
This research looks at why the BubR1 protein breaks down as we age or under stress and seeks ways to preserve it to help prevent age-related problems like cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Creighton University NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | June 1, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $298,275 |
| NIH project number | 5R01AG077574-05 |
| Project ID | NIH-11308261 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older adults or people with age-related cancers who are willing to donate tissue or samples or who want to follow future therapies targeting BubR1 regulation are the most relevant group.
✕Less likely to help
People seeking immediate treatments or those without age-related conditions are unlikely to gain direct, near-term benefit from this lab-focused work.
What this research studies
BubR1 helps cells divide correctly and prevents cells from becoming senescent or cancerous, but its levels fall with age. The team will study how an enzyme complex (including the E3 ligase β-TRCP1) and the deacetylase SIRT2 control BubR1’s tagging for destruction, and how low-nutrient stress like glucose deprivation affects this process. Experiments will use cell models and molecular methods, and may include animal models and human-derived samples to trace the pathway. Findings will guide strategies to stop unwanted BubR1 loss during aging and stress.
Why it matters
Potential benefit: If successful, the work could point to ways to keep BubR1 stable and reduce cellular aging and cancer risk.
How similar studies have gone: Previous work showed SIRT2 can block BubR1 degradation in cells and models, but targeting the β-TRCP1 ubiquitin pathway for BubR1 is a newer, less-tested approach.
Where this research is happening
-
Creighton University
Omaha, United States Active
Researchers
- Principal investigator: North, Brian J. — Creighton University
- Study coordinator: North, Brian J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.