Keeping people on buprenorphine using a smartphone virtual helper

Sustaining recovery for people on opioid agonist treatment with conversational agents

['FUNDING_OTHER'] · BOSTON MEDICAL CENTER · NIH-11166409

A smartphone app with an animated chat helper designed to support people taking buprenorphine for opioid use disorder stay connected to care and cope with stigma and stress.

Quick facts

Phase['FUNDING_OTHER']
Study typeNih_funding
SexAll
SponsorBOSTON MEDICAL CENTER (nih funded)
Locations1 site (BOSTON, UNITED STATES)
Trial IDNIH-11166409 on ClinicalTrials.gov

What this research studies

You would use a smartphone app that features an animated conversational agent which talks with you like a coach. The agent delivers acceptance-based coping skills from cognitive-behavioral therapy, motivational interviewing, mindfulness exercises, educational stories, and interactive activities focused on medication and stigma-related challenges. Participants will interact with the agent and give feedback so the app is easy to use and helpful in real recovery situations. If someone is in crisis or at higher relapse risk, the app can connect them with clinic resources or escalation pathways.

Who could benefit from this research

Good fit: People currently receiving buprenorphine for opioid use disorder who have a smartphone and are willing to use an app-based recovery support tool would be ideal candidates.

Not a fit: People not on buprenorphine, without reliable smartphone access, or with severe uncontrolled medical or psychiatric conditions may not be helped by this intervention.

Why it matters

Potential benefit: If successful, the app could help more people stay on buprenorphine longer, reduce relapse risk, and improve coping with stigma and isolation.

How similar studies have performed: Animated conversational agents and acceptance-based stigma interventions have shown promise in prior trials, though this specific smartphone ECA approach for buprenorphine retention is relatively new.

Where this research is happening

BOSTON, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.