Keeping Golgi membrane proteins balanced in cells
Molecular mechanisms of membrane protein homeostasis at the Golgi
This project looks at how cells keep Golgi membrane proteins in balance, which could matter for people with congenital glycosylation disorders, some cancers, or immune problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-11321578 on NIH RePORTER |
What this research studies
If you or a loved one has a congenital disorder of glycosylation, certain cancers, or immune problems, this lab is studying how proteins in the Golgi are sorted and recycled inside cells. Researchers combine genetic experiments, flow cytometry, advanced imaging, lab-made membrane reconstitution, and proteomics to find the molecules that control where Golgi proteins go. They have already discovered new transmembrane components that help recycle specific Golgi enzymes. Over the next five years they will map recycling receptors across Golgi compartments and detail the mechanisms that keep the Golgi working properly.
Who could benefit from this research
Good fit: People diagnosed with congenital disorders of glycosylation, patients with cancers linked to Golgi dysfunction, or individuals with related immune disorders are the most likely to be interested in or affected by this research.
Not a fit: Patients seeking immediate clinical treatments should not expect direct benefit because this grant supports basic lab research rather than a clinical trial.
Why it matters
Potential benefit: If successful, the work could identify new molecular targets for diagnostics or treatments for congenital glycosylation disorders, some cancers, and immune-related diseases.
How similar studies have performed: Previous research has uncovered some Golgi recycling components and disease links, but much of the molecular mechanism remains novel and not yet translated into therapies.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Sardana, Richa — Cornell University
- Study coordinator: Sardana, Richa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.