Johns Hopkins emergency care trials hub to speed better treatments
Network for Emergency Care Clinical Trials: Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN)
Building a Johns Hopkins-led emergency care network to speed up and improve clinical trials for people who come to the emergency department with sudden, serious illnesses or injuries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11286844 on NIH RePORTER |
What this research studies
If I go to a participating emergency department or am treated by partner EMS, this hub will coordinate clinical trials across many hospitals so more patients can be enrolled quickly. The Johns Hopkins Hub-and-Spoke model links nine committed partner institutions and over 25 clinical sites across five states and Washington, DC, with an annual emergency department census exceeding 1.6 million. The hub handles recruitment, trial logistics, and collaboration with EMS to make it easier to run studies for neurologic, cardiac, respiratory, hematologic, and traumatic emergencies. This network infrastructure is designed to enable rapid, well-run emergency care trials that reach patients when time matters most.
Who could benefit from this research
Good fit: Ideal candidates are people who present to participating emergency departments or are cared for by affiliated EMS with acute neurologic, cardiac, respiratory, hematologic, or traumatic conditions and who meet trial-specific eligibility rules.
Not a fit: People who are not treated at a participating site, who have stable chronic conditions not needing emergency care, or who do not meet specific trial inclusion criteria are unlikely to benefit directly from this network.
Why it matters
Potential benefit: If successful, the hub could speed development and delivery of better emergency treatments and improve outcomes for people with sudden, life-threatening conditions.
How similar studies have performed: Existing emergency-care research networks have successfully run large trials before, and SIREN builds on that proven model to expand capacity and coordination.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Kelen, Gabor D — Johns Hopkins University
- Study coordinator: Kelen, Gabor D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.