Johns Hopkins continuation of the Chronic Kidney Disease (CRIC) cohort
Official title: Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Hopkins Clinical Center
Funded at Johns Hopkins University · NIH-11131114 · Data updated 2026-11-12
This project continues long-term follow-up of adults with chronic kidney disease to collect health information, tests, and samples that help understand kidney and heart complications.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 28, 2001 |
| Project end | June 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $300,391 |
| NIH project number | 5U01DK061022-25 |
| Project ID | NIH-11131114 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with reduced kidney function (chronic kidney disease), especially current or former CRIC participants or people meeting CRIC enrollment criteria, are the ideal candidates.
✕Less likely to help
People without chronic kidney disease or those seeking immediate treatment changes are unlikely to receive direct clinical benefit because this is an observational follow-up rather than a treatment trial.
What this research studies
If you take part, the team will continue regular follow-up visits and collect biological samples, clinical tests, and questionnaires to track your kidney and cardiovascular health. They will link your health records with external data sources when possible to capture hospital events and long-term outcomes. The researchers will combine lab results, imaging, and other measurements to identify groups who progress differently and to relate earlier tests to later health events. The study will complete final visits for eligible participants and build data and biospecimen resources for future researchers.
Why it matters
Potential benefit: If successful, this work could improve predictions of who will worsen from chronic kidney disease and guide future strategies to prevent kidney failure and heart complications.
How similar studies have gone: CRIC is a long-established, landmark cohort of over 5,600 participants that has already produced many findings linking kidney measures to cardiovascular and other outcomes, so this continuation builds on proven success.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Appel, Lawrence John — Johns Hopkins University
- Study coordinator: Appel, Lawrence John
Related research
Other NIH-funded projects on the same topics.
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Chronic Renal Insufficiency Cohort: Phase 5 SDCC Support
This grant funds a central coordinating center to oversee a long-term study of adults with reduced kidney function and related health outcomes.
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Chronic Kidney Disease and Aortic Valve Disease: Understanding How Kidney Disease Influences Aortic Stenosis
This grant looks at how chronic kidney disease may affect the progression of aortic stenosis and whether we can find ways to slow it down for adults with kidney issues.
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Understanding Kidney Disease and Heart Health
This long-running project gathers information from people with reduced kidney function to better understand how kidney disease progresses and affects heart health.
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Tracking kidney disease and heart health in adults
This project follows adults with reduced kidney function to learn how kidney disease progresses and how it affects heart health and other health problems.
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Tulane Chronic Kidney Disease (CKD) Cohort
Following thousands of adults with reduced kidney function to learn what factors influence kidney decline and heart disease risk.
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Long-term chronic kidney disease follow-up at Case Western Reserve
Researchers will continue following adults with chronic kidney disease to track kidney health and heart problems over time.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.