J147 treatment for brain injuries and recovery
J147 Treatment for Traumatic Brain Injury in Brain Damage and Long-Term Functional Recovery
This study is looking at a special compound called J147 to see if it can help protect the brain and improve recovery after a traumatic brain injury, using mice to find out how it works and if it can lead to better treatments for people with this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-10372618 on NIH RePORTER |
What this research studies
This research investigates the potential of J147, a curcumin-derived compound, to protect the brain and enhance recovery after traumatic brain injury (TBI). The study aims to understand how J147 can prevent further brain damage and improve neurological functions over time. Using a mouse model, researchers will explore the effects of J147 on neuronal health and recovery, focusing on its ability to cross the blood-brain barrier and its neuroprotective properties. The ultimate goal is to develop a new therapeutic approach for TBI that could lead to better long-term outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have experienced a traumatic brain injury.
Not a fit: Patients with pre-existing severe neurological conditions or those who are not able to participate in the treatment protocol may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a new treatment that significantly improves recovery and quality of life for individuals suffering from traumatic brain injuries.
How similar studies have performed: While J147 has shown promise in other neurodegenerative conditions, its application in traumatic brain injury is novel and has not been extensively tested in clinical settings.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: Jin, Rong — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Jin, Rong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.