Ischemic kidney injury and kidney repair in veterans
Official title: Ischemic kidney injury and kidney repair
Funded at Charlie Norwood VA Medical Center · NIH-11184730 · Data updated 2026-11-12
A study exploring how kidney injury heals after damage, with a focus on veterans who may be at higher risk for long-term kidney problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Charlie Norwood VA Medical Center NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | April 1, 2026 |
| Project end | March 31, 2030 |
| Funding year | 2026 |
| NIH project number | 2I01BX000319-17 |
| Project ID | NIH-11184730 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with recent or past acute kidney injury, especially veterans, who are at risk for developing CKD.
✕Less likely to help
Patients without AKI history or those not at risk for CKD may not directly benefit.
What this research studies
This project looks at why kidneys sometimes repair damaged tissue in a way that leads to scarring and chronic kidney problems after an acute injury. It will examine a process called SUMOylation, a cellular modification, to see how it affects repair and fibrosis in the kidney. By studying veterans and the mechanisms behind maladaptive repair, the research aims to identify new points for intervention. The findings could point toward strategies to prevent progression from acute injury to chronic disease.
Why it matters
Potential benefit: If successful, the work could lead to new approaches to prevent kidney fibrosis and CKD after AKI, potentially improving long-term kidney health for affected patients.
How similar studies have gone: There is a growing but still developing body of work on kidney repair and fibrosis, with some progress in related pathways but SUMOylation in maladaptive repair is an emerging area.
Where this research is happening
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Charlie Norwood VA Medical Center
Augusta, United States Active
Researchers
- Principal investigator: Dong, Zheng — Charlie Norwood VA Medical Center
- Study coordinator: Dong, Zheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.