Iris stiffness and why narrow-angle glaucoma affects women more
The role of iris biomechanics and sex differences in primary angle-closure glaucoma
['FUNDING_OTHER'] · UNIVERSITY OF SOUTH FLORIDA · NIH-11181568
This work looks at whether differences in iris stiffness and sex explain why people, especially women, develop primary angle-closure glaucoma.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTH FLORIDA (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-11181568 on ClinicalTrials.gov |
What this research studies
You would have non-invasive eye tests that measure how your pupil and iris move in response to light and specialized imaging of the front of the eye. The team will compare measurements from people with a history of angle-closure glaucoma to those without to see if iris biomechanics differ. They will also explore whether sex-related differences help explain the higher rates in women, and may use lab or animal models to study underlying biology. The focus is on human eye data but includes complementary laboratory work to clarify mechanisms.
Who could benefit from this research
Good fit: Ideal candidates are adults with narrow anterior chamber angles, a history of primary angle-closure glaucoma, or those at higher risk (older age, especially women) who can attend in-person eye exams.
Not a fit: People with other forms of glaucoma (such as primary open-angle glaucoma), unrelated eye diseases, or those unable to attend in-person testing are less likely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this could help doctors spot people at higher risk of angle-closure glaucoma earlier and lead to better targeted prevention or treatment strategies.
How similar studies have performed: Previous work has shown irises are often stiffer in people with angle-closure glaucoma and that pupillary reflex tests can measure iris mechanics, but applying these findings to explain sex differences and predict angle closure is newer.
Where this research is happening
TAMPA, UNITED STATES
- UNIVERSITY OF SOUTH FLORIDA — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NAGHIZADEHSAFA, BABAK — UNIVERSITY OF SOUTH FLORIDA
- Study coordinator: NAGHIZADEHSAFA, BABAK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.