Ion channels that help antibody-producing cells develop
Ion channels regulating plasma cell differentiation and humoral immunity
['FUNDING_R01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11222694
This research looks at whether certain ion channels control how antibody-making plasma cells form, which is important for people with antibody deficiencies or weak vaccine protection.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11222694 on ClinicalTrials.gov |
What this research studies
From your perspective, this research looks at tiny channels in immune cells that help turn B cells into antibody-making plasma cells. Researchers use lab experiments, genetic testing, and blood or tissue samples from patients to see how mutations or changes affect antibody production. They compare samples from people with antibody deficiencies (like agammaglobulinemia or CVID) and from healthy donors to spot key differences. The goal is to identify channels that could be targeted to boost antibody responses or help diagnose inherited antibody problems.
Who could benefit from this research
Good fit: People with inherited or unexplained low antibody levels (for example agammaglobulinemia or common variable immunodeficiency), recurrent infections, or poor responses to vaccines would be most relevant to this work.
Not a fit: People with health problems unrelated to antibody production, such as many purely metabolic or structural conditions, are unlikely to see direct benefit from this research.
Why it matters
Potential benefit: If successful, this work could lead to new tests or treatments that improve antibody production in people with immunodeficiencies or poor vaccine responses.
How similar studies have performed: Previous studies have linked some ion channel mutations to B cell defects, but turning that knowledge into ways to restore antibody production remains largely experimental.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FESKE, STEFAN — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: FESKE, STEFAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus