Investigating youth-onset type 2 diabetes and its complications
Understanding and Targeting the Pathophysiology of Youth-onset Type 2 Diabetes- NYU Clinical Center
This study is looking at the causes and effects of type 2 diabetes in kids and teens to find out what makes it worse and how we can better treat it, so if you or someone you know is at risk, this research could help improve their care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11045701 on NIH RePORTER |
What this research studies
This research focuses on understanding the unique characteristics of youth-onset type 2 diabetes (T2D), which is increasing in prevalence among children and adolescents. The study aims to identify risk factors and biomarkers that contribute to the rapid progression of this condition, including genetic, psychosocial, and environmental influences. By conducting a prospective cohort study of high-risk youth, researchers will gather data to develop predictive models that could lead to targeted therapies. The role of soluble receptors of Advanced Glycation End Products (sRAGE) in insulin resistance and beta-cell dysfunction will also be explored, as it may provide insights into the complications associated with youth-onset T2D.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and adolescents at high risk for developing type 2 diabetes, particularly those with a family history or other risk factors.
Not a fit: Patients who are not at risk for type 2 diabetes or who are already diagnosed with adult-onset diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for youth-onset type 2 diabetes, ultimately reducing its severity and associated complications.
How similar studies have performed: Previous research has shown success in understanding adult-onset type 2 diabetes, but the specific focus on youth-onset T2D and its unique pathophysiology is relatively novel.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Gallagher, Mary Patricia — New York University School of Medicine
- Study coordinator: Gallagher, Mary Patricia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.