Investigating youth-onset type 2 diabetes and its complications
Official title: Understanding and Targeting the Pathophysiology of Youth-onset Type 2 Diabetes- NYU Clinical Center
Funded at New York University School of Medicine · NIH-11045701 · Data updated 2026-11-12
This study is looking at the causes and effects of type 2 diabetes in kids and teens to find out what makes it worse and how we can better treat it, so if you or someone you know is at risk, this research could help improve their care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 17, 2023 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $750,256 |
| NIH project number | 5U01DK135012-03 |
| Project ID | NIH-11045701 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and adolescents at high risk for developing type 2 diabetes, particularly those with a family history or other risk factors.
✕Less likely to help
Patients who are not at risk for type 2 diabetes or who are already diagnosed with adult-onset diabetes may not benefit from this research.
What this research studies
This research focuses on understanding the unique characteristics of youth-onset type 2 diabetes (T2D), which is increasing in prevalence among children and adolescents. The study aims to identify risk factors and biomarkers that contribute to the rapid progression of this condition, including genetic, psychosocial, and environmental influences. By conducting a prospective cohort study of high-risk youth, researchers will gather data to develop predictive models that could lead to targeted therapies. The role of soluble receptors of Advanced Glycation End Products (sRAGE) in insulin resistance and beta-cell dysfunction will also be explored, as it may provide insights into the complications associated with youth-onset T2D.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for youth-onset type 2 diabetes, ultimately reducing its severity and associated complications.
How similar studies have gone: Previous research has shown success in understanding adult-onset type 2 diabetes, but the specific focus on youth-onset T2D and its unique pathophysiology is relatively novel.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Gallagher, Mary Patricia — New York University School of Medicine
- Study coordinator: Gallagher, Mary Patricia
Related research
Other NIH-funded projects on the same topics.
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Subtyping Core for Research on the Causes of Type 2 Diabetes (SCORE-T2D)
A new U01 grant from a university research team aims to understand why Type 2 diabetes differs so much between people and how to tailor prevention and treatment.
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Michigan Diabetes Project: A Peer-Led Self-Management Program for Adults with Type 2 Diabetes
A peer-led self-management program for adults with type 2 diabetes is being tested to see if it improves blood sugar control and daily diabetes care.
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Alzheimer’s and dementia risk in people with prediabetes or type 2 diabetes
This grant aims to understand why some older adults with prediabetes or type 2 diabetes develop memory problems or dementia.
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Personalized use of newer diabetes medicines for Type 2 diabetes
Aiming to tailor use of newer glucose-lowering drugs for people with type 2 diabetes to improve health and access in real-world settings.
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Alzheimer’s and related dementia in older adults with prediabetes or type 2 diabetes
This grant aims to understand why cognitive problems occur in people 65 and older who have prediabetes or type 2 diabetes, using data from a long-running diabetes study to identify what drives memory and thinking decline.
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Understanding why youth develop type 2 diabetes and how to prevent it
A nationwide study aims to unravel why some teens with obesity develop type 2 diabetes while others don’t, and to identify factors that could help prevent it.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.