Investigating why women are more affected by Alzheimer's Disease than men
Integrative genomic, transcriptomic, and proteomic analyses to investigate sex-specific differences in Alzheimer's Disease
This study is looking at how being male or female affects the way genes work in the brains of people with Alzheimer's Disease, and it hopes to find important clues that could lead to better treatments, with the help of patients who can provide brain samples.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11159316 on NIH RePORTER |
What this research studies
This research explores the differences in Alzheimer's Disease (AD) between sexes, focusing on how biological sex influences gene expression in the brain. The team will analyze brain tissue to identify genetic factors that may contribute to the higher risk of AD in women compared to men. By examining both transcript and protein levels, the study aims to pinpoint specific genetic variations that could lead to better understanding and potential treatments for AD. Patients may be involved in providing biological samples to help uncover these critical insights.
Who could benefit from this research
Good fit: Ideal candidates for participation include women at risk for Alzheimer's Disease or those diagnosed with early-stage AD.
Not a fit: Patients who are men or those with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that address the unique risk factors for Alzheimer's Disease in women.
How similar studies have performed: Previous research has successfully identified genetic factors related to Alzheimer's Disease, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Wingo, Thomas Spurgeon — University of California at Davis
- Study coordinator: Wingo, Thomas Spurgeon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.