Investigating why some children with asthma don't respond to corticosteroids
Airway Structural Cells and Corticosteroid Resistance in Asthma
This study is looking into why some kids with severe asthma don't respond well to corticosteroid treatments, by exploring how certain proteins affect the cells in their airways, and it hopes to find new ways to help manage their asthma better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-11226775 on NIH RePORTER |
What this research studies
This research focuses on understanding the reasons behind corticosteroid resistance in children with severe asthma. It examines how specific proteins, such as IFNγ and TNFα, affect airway smooth muscle cells, which play a crucial role in regulating airway function. By using both mouse and human models, the study aims to uncover the biological mechanisms that lead to persistent airway inflammation and hyperresponsiveness despite corticosteroid treatment. The findings could help identify new therapeutic strategies for managing severe asthma in children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children with severe asthma who exhibit resistance to corticosteroid treatments.
Not a fit: Patients with mild asthma or those who respond well to corticosteroid therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for children with severe asthma who currently do not respond to standard corticosteroid therapies.
How similar studies have performed: Previous research has shown associations between inflammatory pathways and corticosteroid resistance, suggesting that this area of investigation has potential for significant breakthroughs.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Britt, Rodney — Research Inst Nationwide Children's Hosp
- Study coordinator: Britt, Rodney
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.