Investigating why men and women experience Lewy body dementia differently
Genetic and Neuropathologic Underpinnings of Sex Differences in Lewy Body Dementias
This study is looking at how Lewy body dementia affects men and women differently, especially in relation to Alzheimer's disease, to help doctors better understand symptoms and improve diagnosis for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11130093 on NIH RePORTER |
What this research studies
This research explores the differences in Lewy body dementia between men and women, focusing on genetic and pathological factors. It aims to understand how Alzheimer's disease-related genetic risks may contribute to higher dementia risk in women, particularly due to the co-occurrence of Alzheimer's pathology. The study will analyze the distribution of Lewy body and Alzheimer's pathology in the brain to identify sex-specific patterns and symptoms. By developing models that incorporate clinical and genetic data, the research seeks to improve diagnostic accuracy and patient selection for future clinical trials.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Lewy body dementia, especially women who may also have Alzheimer's pathology.
Not a fit: Patients with Lewy body dementia who do not have any Alzheimer's-related pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and treatment strategies for Lewy body dementia, particularly for women.
How similar studies have performed: Previous research has indicated that understanding sex differences in dementia can lead to improved diagnostic and treatment approaches, suggesting potential success for this study's approach.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Bayram, Ece — University of Colorado Denver
- Study coordinator: Bayram, Ece
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.