Investigating why Black women with ovarian cancer have worse survival rates than White women
Methylomic basis of survival disparities among Black and White women with high-grade serous ovarian cancer
This study is looking into why Black and White women with high-grade serous ovarian cancer have different survival rates, by exploring how lifestyle and cultural factors might affect their tumors, with the hope of finding new ways to improve treatment for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11002651 on NIH RePORTER |
What this research studies
This research aims to understand the reasons behind the survival disparities in high-grade serous ovarian cancer between Black and White women. By examining DNA methylation patterns, the study will explore how lifestyle and sociocultural factors may influence tumor characteristics and outcomes. The research will utilize data from established observational studies to identify unique methylomic signatures that could explain the differences in survival rates. Ultimately, the goal is to uncover novel prognostic factors that could lead to improved treatment strategies for underrepresented groups.
Who could benefit from this research
Good fit: Ideal candidates for this research are Black women diagnosed with high-grade serous ovarian cancer.
Not a fit: Patients who are not diagnosed with ovarian cancer or who do not identify as Black may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted interventions that improve survival rates for Black women with ovarian cancer.
How similar studies have performed: While research on ovarian cancer has been extensive, this specific focus on methylomic differences among racial groups is relatively novel and has not been widely tested.
Where this research is happening
Tampa, United States
- H. Lee Moffitt Cancer Ctr & Res Inst — Tampa, United States (Active)
Researchers
- Principal investigator: Peres, Lauren Cole — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Peres, Lauren Cole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.