Investigating why Black women with ovarian cancer have worse survival rates than White women

Who could benefit from this research

What this research studies

This research aims to understand the reasons behind the survival disparities in high-grade serous ovarian cancer between Black and White women. By examining DNA methylation patterns, the study will explore how lifestyle and sociocultural factors may influence tumor characteristics and outcomes. The research will utilize data from established observational studies to identify unique methylomic signatures that could explain the differences in survival rates. Ultimately, the goal is to uncover novel prognostic factors that could lead to improved treatment strategies for underrepresented groups.

Why it matters

Where this research is happening

• H. Lee Moffitt Cancer Ctr & Res Inst
  Tampa, United States Active

Researchers

• Principal investigator: Peres, Lauren Cole — H. Lee Moffitt Cancer Ctr & Res Inst
• Study coordinator: Peres, Lauren Cole

Related research

Other NIH-funded projects on the same topics.

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• Photodynamic lipids to boost chemotherapy for metastatic ovarian cancer

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• Integrated framework to validate and quantify proteoforms in patient-derived ovarian cancer cells

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  NIH research University of Alabama in Tuscaloosa · Tuscaloosa, United States · NIH-11566393

• Overcoming platinum resistance in ovarian cancer: finding biomarkers and new targets

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  NIH research VA Greater Los Angeles Healthcare System · Los Angeles, United States · NIH-11498011

• Alternative NF-kB activation after chemotherapy in ovarian cancer

  This grant studies how ovarian cancer might come back after chemotherapy by looking at specific signaling pathways in cancer cells and the tumor environment.

  NIH research San Diego State University · San Diego, United States · NIH-11473227

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.