Investigating why arteriovenous fistulas fail in patients with kidney disease
Catheter-associated molecular patterns and arteriovenous fistula failure
This study is looking into why some arteriovenous fistulas (AVFs) don’t work well for people on hemodialysis, especially how central venous catheters (CVCs) might cause problems, and it hopes to find ways to help more AVFs succeed.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11011503 on NIH RePORTER |
What this research studies
This research focuses on understanding the reasons behind the failure of arteriovenous fistulas (AVFs), which are crucial for patients undergoing hemodialysis. It examines the role of central venous catheters (CVCs) and how they may contribute to complications in AVF maturation due to immune responses. By analyzing the molecular patterns and immune cell activity in patients, the study aims to identify potential preventive measures to improve AVF success rates. The research employs a combination of biological assays and patient data to explore these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with end-stage kidney disease who are starting hemodialysis and may require an arteriovenous fistula for vascular access.
Not a fit: Patients who are not undergoing hemodialysis or those who do not require vascular access for kidney treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for ensuring the successful maturation of arteriovenous fistulas, enhancing the quality of life for patients requiring hemodialysis.
How similar studies have performed: Previous research has indicated that immune responses play a significant role in vascular access complications, suggesting that this approach could yield valuable insights.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Martinez, Laisel — University of Miami School of Medicine
- Study coordinator: Martinez, Laisel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.