Investigating why antifungal treatments fail in patients with invasive fungal infections
Antifungal antagonism as a cause of treatment failure for invasive mycoses
This study is looking into why some treatments for serious fungal infections, especially those caused by Aspergillus fumigatus, don’t work as well as they should, and it aims to find ways to improve these treatments by understanding both the fungus and the patients better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11042267 on NIH RePORTER |
What this research studies
This research focuses on understanding the reasons behind treatment failures in patients suffering from invasive fungal infections, particularly those caused by the fungus Aspergillus fumigatus. It examines the effectiveness of current antifungal therapies and explores factors that may contribute to poor patient outcomes, such as drug resistance and host-related issues. By analyzing the discrepancies between laboratory tests and actual patient responses, the research aims to identify potential improvements in antifungal treatment strategies. Patients may be involved in providing samples or data to help uncover these critical insights.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with invasive fungal infections who are currently undergoing antifungal treatment.
Not a fit: Patients with non-invasive fungal infections or those who are not receiving antifungal therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective antifungal treatments and improved survival rates for patients with invasive fungal infections.
How similar studies have performed: Previous research has shown that understanding drug resistance mechanisms can lead to significant advancements in treatment efficacy, suggesting that this approach may yield valuable insights.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Palmer, Glen — University of Tennessee Health Sci Ctr
- Study coordinator: Palmer, Glen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.