Investigating ways to regenerate optic nerves in glaucoma patients
Phosphoinositide Signaling and Optic Nerve Regeneration
['FUNDING_OTHER'] · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · NIH-11052223
This study is looking at ways to help heal damaged optic nerves in people with glaucoma by exploring how certain processes in the eye can be used to support the recovery of vision.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VETERANS ADMIN PALO ALTO HEALTH CARE SYS (nih funded) |
| Locations | 1 site (PALO ALTO, UNITED STATES) |
| Trial ID | NIH-11052223 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how specific signaling pathways in the eye can be targeted to promote the regeneration of optic nerves damaged by glaucoma. Using a mouse model that mimics glaucoma, researchers will explore the role of phosphoinositide metabolism and endoplasmic reticulum stress in enhancing the recovery of retinal ganglion cells. By examining these pathways, the study aims to develop new therapeutic strategies that could lead to improved vision restoration for patients suffering from glaucoma-related blindness.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with glaucoma who are experiencing vision loss.
Not a fit: Patients with other types of optic nerve damage unrelated to glaucoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that restore vision in patients with glaucoma by promoting optic nerve regeneration.
How similar studies have performed: Previous research has shown promise in targeting similar pathways for nerve regeneration, indicating potential for success in this approach.
Where this research is happening
PALO ALTO, UNITED STATES
- VETERANS ADMIN PALO ALTO HEALTH CARE SYS — PALO ALTO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUN, YANG — VETERANS ADMIN PALO ALTO HEALTH CARE SYS
- Study coordinator: SUN, YANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: axon injury, axonal injury