Investigating ways to regenerate optic nerves in glaucoma patients
Official title: Phosphoinositide Signaling and Optic Nerve Regeneration
Funded at Veterans Admin Palo Alto Health Care Sys · NIH-11052223 · Data updated 2026-11-12
This study is looking at ways to help heal damaged optic nerves in people with glaucoma by exploring how certain processes in the eye can be used to support the recovery of vision.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Admin Palo Alto Health Care Sys NIH-funded |
| Lab location | 1 site (Palo Alto, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| NIH project number | 1I01BX006638-01A1 |
| Project ID | NIH-11052223 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with glaucoma who are experiencing vision loss.
✕Less likely to help
Patients with other types of optic nerve damage unrelated to glaucoma may not benefit from this research.
What this research studies
This research focuses on understanding how specific signaling pathways in the eye can be targeted to promote the regeneration of optic nerves damaged by glaucoma. Using a mouse model that mimics glaucoma, researchers will explore the role of phosphoinositide metabolism and endoplasmic reticulum stress in enhancing the recovery of retinal ganglion cells. By examining these pathways, the study aims to develop new therapeutic strategies that could lead to improved vision restoration for patients suffering from glaucoma-related blindness.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that restore vision in patients with glaucoma by promoting optic nerve regeneration.
How similar studies have gone: Previous research has shown promise in targeting similar pathways for nerve regeneration, indicating potential for success in this approach.
Where this research is happening
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Veterans Admin Palo Alto Health Care Sys
Palo Alto, United States Active
Researchers
- Principal investigator: Sun, Yang — Veterans Admin Palo Alto Health Care Sys
- Study coordinator: Sun, Yang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.