Investigating ways to regenerate corneal nerves
New models, new approaches, new horizons in corneal nerve regeneration
['FUNDING_R01'] · UNIVERSITY OF PENNSYLVANIA · NIH-11058493
This study is looking at how to help damaged nerves in the eye heal better, especially by understanding how certain receptors work, which could lead to new treatments for people with corneal nerve issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11058493 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how corneal nerves, which are crucial for eye health, can regenerate after injury. The team will explore the molecular mechanisms involved in this process, particularly the role of N-Methyl-D-aspartate receptors (NMDARs) in enhancing nerve regeneration. By using advanced techniques like 2-photon microscopy, they aim to identify new therapeutic approaches that could restore corneal nerve density and function. This could lead to innovative treatments for patients suffering from corneal nerve damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced corneal nerve damage due to trauma, infections, or surgical interventions.
Not a fit: Patients with intact corneal nerves or those with conditions unrelated to nerve regeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve corneal health and restore vision for patients with nerve injuries.
How similar studies have performed: Previous research has shown that NMDARs can enhance nerve regeneration in other parts of the peripheral nervous system, suggesting potential for success in this novel application.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEE, VIVIAN — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: LEE, VIVIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.