Investigating ways to reduce muscle fatigue in breast cancer patients
Targeting Muscle Fatigability During Cachexia
This study is looking at how breast cancer and its treatment can make muscles feel tired and weak, and it aims to find ways to help improve muscle function and overall quality of life for patients dealing with this issue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | West Virginia University NIH-funded |
| Lab location | 1 site (Morgantown, United States) |
| Project ID | NIH-11075824 on NIH RePORTER |
What this research studies
This research focuses on understanding and addressing muscle fatigue experienced by breast cancer patients, which can worsen during treatment. By using animal models, the study aims to explore how breast tumors affect muscle function and identify potential therapeutic targets to alleviate this fatigue. The researchers will investigate the role of mitochondrial bioenergetics and specific molecular interactions that contribute to muscle dysfunction. The ultimate goal is to find effective treatments that can improve the quality of life for patients suffering from this debilitating side effect.
Who could benefit from this research
Good fit: Ideal candidates for this research are breast cancer patients experiencing muscle fatigue, particularly those undergoing or having undergone chemotherapy, radiation, or surgery.
Not a fit: Patients with breast cancer who do not experience muscle fatigue or those in very early stages of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce muscle fatigue in breast cancer patients, enhancing their overall treatment experience.
How similar studies have performed: While the approach of targeting muscle fatigue in cancer patients is gaining attention, this specific investigation into mitochondrial bioenergetics and PPARγ-agonists is relatively novel and has not been extensively tested.
Where this research is happening
Morgantown, United States
- West Virginia University — Morgantown, United States (Active)
Researchers
- Principal investigator: Pistilli, Emidio Edward — West Virginia University
- Study coordinator: Pistilli, Emidio Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.