Investigating ways to reduce damage from radiation exposure
Official title: Radiation Mitigators Targeting Regulated Necrosis Pathways of Parthanatos Pyroptosis
Funded at Columbia University Health Sciences · NIH-10862742 · Data updated 2026-11-12
This study is looking for new ways to help people recover from radiation exposure by finding treatments that can protect their cells from damage, which could be especially helpful for patients who have had radiation therapy or been in accidents.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 8, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $358,366 |
| NIH project number | 5U01AI156923-05 |
| Project ID | NIH-10862742 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have been exposed to radiation due to accidents or medical treatments.
✕Less likely to help
Patients who have not been exposed to radiation or are not at risk of radiation exposure may not receive any benefit from this research.
What this research studies
This research focuses on developing treatments that target specific pathways involved in cell death caused by radiation exposure. By understanding how regulated necrosis pathways, particularly those related to Parthanatos and Pyroptosis, function, the researchers aim to create effective mitigators that can protect cells from radiation-induced damage. Patients may benefit from new therapies that could enhance recovery after radiation exposure from accidents or medical treatments. The approach involves laboratory studies to identify and test potential compounds that can intervene in these cell death pathways.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the harmful effects of radiation exposure on patients.
How similar studies have gone: While the specific pathways being targeted are novel, there has been previous research indicating that targeting cell death mechanisms can be beneficial in mitigating damage from various stressors.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Bayir, Hülya — Columbia University Health Sciences
- Study coordinator: Bayir, Hülya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.