Investigating ways to prevent nerve cell damage in Huntington's disease
Modulation of neuronal atrophy in Huntington's disease
This study is looking at how certain proteins affect the health of nerve cells in people with Huntington's disease, with the hope of finding new ways to protect these cells and improve treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10475665 on NIH RePORTER |
What this research studies
This research focuses on Huntington's disease, a genetic disorder that leads to the degeneration of nerve cells in the brain. The team is exploring how specific proteins and molecular pathways contribute to the atrophy of neurons, particularly looking at the role of Rho GTPases and ARAP3 in maintaining neuronal health. By studying both human brain samples and transgenic animal models, the researchers aim to identify potential therapeutic targets that could reverse or mitigate neuronal damage. Patients may benefit from insights gained into how to protect their nerve cells from degeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Huntington's disease, particularly those in the early to mid-stages of the condition.
Not a fit: Patients with advanced Huntington's disease or those without the genetic mutation associated with the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of Huntington's disease.
How similar studies have performed: Previous research has shown promising results in targeting similar molecular pathways in neurodegenerative diseases, indicating potential for success in this approach.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Lee, Junghee — Boston University Medical Campus
- Study coordinator: Lee, Junghee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.